C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 453/02 (2006.01) A61K 31/44 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2042336
ABSTRACT OF THE DISCLOSURE Compounds of formula (I): Image (I) [in which: R1 is hydrogen, halogen or alkyl; R2 is hydrogen, alkyl, optionally substituted phenyl or a heterocycle; or R1 and R2 together form a group of formula -CR4=CR5-CR6=CR7-, where R4, R5, R6 and R7 are hydrogen, halogen, alkyl group, alkoxy, halomethyl, alkylamino, dialkylamino, hydroxy, nitro, aliphatic carboxylic acylamino or amino; and R3 is piperidyl, substituted piperidyl or quinuclidinyl] are useful in the treatment and prophylaxis of cognitive disorders, notably senile dementia, including Alzheimer's disease. Processes for preparing the compounds are also provided.
Iwata Nobuyoshi
Kobayashi Takeo
Kozuka Masao
Kubo Yoshiko
Nagano Mitsuo
Marks & Clerk
Sankyo Company Limited
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