Pirfenidone treatment for patients with atypical liver function

Details Pirfenidone treatment for patients with atypical liver function Pirfenidone treatment for patients with atypical liver function

A - Human Necessities

61

K

A61K 31/4412 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2709997

Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone administration. The methods include administering to a patient pirfenidone at doses lower than the full target dosage for a time period, followed by administering to the patient pirfenidone at the full target dosage. The methods also include administering pirfenidone at the full target dose with no reduction and administering permanently reduced doses of pirfenidone.

La présente invention a pour objet des méthodes dadministration de pirfénidone à un patient qui a présenté des biomarqueurs anormaux de la fonction hépatique en réponse à ladministration de pirfénidone. Les méthodes comprennent ladministration à un patient de pirfénidone à des doses inférieures à la posologie cible complète pendant une période de temps, ceci suivi de ladministration au patient de pirfénidone à la posologie cible complète. Les méthodes comprennent également ladministration de pirfénidone à la posologie cible complète sans réduction et ladministration de manière permanente de doses réduites de pirfénidone.

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