Piscirickettsia salmonis antigens and use thereof

Details Piscirickettsia salmonis antigens and use thereof Piscirickettsia salmonis antigens and use thereof

C - Chemistry, Metallurgy

07

K

C07K 14/29 (2006.01) A61K 39/02 (2006.01) A61K 39/295 (2006.01) C07K 16/12 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2541464

The present invention discloses novel proteins, e.g., antigens, from Piscirickettsia salmonis. The present invention further discloses nucleic acids that encode these proteins. The present invention also discloses the use of the proteins, e.g., antigens, and nucleic acids to prepare vaccines against salmonid rickettsial septicemia (SRS). The present invention further provides recombinant Yersinia ruckeri cells to be used to construct vaccines against SRS. The present invention also discloses vaccines that can be used to protect fish from Piscirickettsia salmonis, as well as other pathogens. In addition, the present invention discloses methods of using the vaccines of the present invention to protect fish from SRS as well as from other pathogenic diseases.

L'invention concerne de nouvelles protéines, par exemple des antigènes, issues de Piscirickettsia salmonis. Elle concerne également des acides nucléiques codant pour ces protéines. Elle concerne aussi l'utilisation de ces protéines, par exemple des antigènes, et des acides nucléiques pour préparer des vaccins contre la septicémie à rickettsies salmonidées (SRS). La présente invention concerne d'autre part des cellules recombinées de Yersinia ruckeri destinées à être utilisées pour assembler des vaccins contre la SRS. Elle concerne également des vaccins pouvant être utilisés pour protéger le poisson contre Piscirickettsia salmonis, ainsi que contre d'autres agents pathogènes. En outre, la présente invention concerne des méthodes d'utilisation de ces vaccins pour protéger le poisson contre la SRS, ainsi que contre d'autres affections pathogènes.

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