Piscirickettsia salmonis antigens and use thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01) A61K 39/295 (2006.01) C07K 14/195 (2006.01) C07K 14/29 (2006.01) C07K 16/12 (2006.01) C12N 1/21 (2006.01)

Patent

CA 2615139

The present invention discloses novel proteins, e.g., antigens, from Piscirickettsia salmonis. The present invention further discloses nucleic acids that encode these proteins. The present invention also discloses the use of the proteins, e.g., antigens, and nucleic acids to prepare vaccines against salmonid rickettsial septicemia (SRS). The present invention further provides recombinant Yersinia ruckeri cells to be used to construct vaccines against SRS. The present invention also discloses vaccines that to can be used to protect fish from Piscirickettsia salmonis, as well as other pathogens. In addition, the present invention discloses methods of using the vaccines of the present invention to protect fish from SRS as well as from other pathogenic diseases.

La présente invention concerne de nouvelles protéines, telles que des antigènes, de Piscirickettsia salmonis. Cette invention concerne également des acides nucléiques qui codent ces protéines. Cette invention concerne en outre l'utilisation des protéines, telles que les antigènes, et des acides nucléiques pour préparer des vaccins contre la septicémie rickettsienne des salmonidés (SRS). Cette invention concerne également des cellules de Yersinia ruckeri de recombinaison destinées à être utilisées pour élaborer des vaccins contre la SRS. Cette invention porte en outre sur des vaccins pouvant être utilisés pour protéger les poissons contre la Piscirickettsia salmonis, ainsi que contre d'autres pathogènes. Cette invention concerne enfin des méthodes d'utilisation des vaccins de cette invention pour protéger les poissons contre la SRS ainsi que contre d'autres maladies pathogènes.

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