Pituitary adenylate cyclase activating peptide (pacap)...

Details Pituitary adenylate cyclase activating peptide (pacap)... Pituitary adenylate cyclase activating peptide (pacap)...

A - Human Necessities

61

K

A61K 38/02 (2006.01)

Patent

CA 2607273

This invention provides peptides with novel modifications that provide suitable derivatization sites to improve the pharmacokinetic properties of the peptides. These modified peptides function in vivo as agonists of the VPAC2 receptor. The peptides of the present invention provide a new therapy for patients with decreased endogenous insulin secretion, for example, type 2 diabetics.

L'invention concerne des peptides présentant de nouvelles modifications qui possèdent des sites de dérivatisation appropriés permettant d'améliorer les propriétés pharmacocinétiques desdits peptides. Lesdits peptides modifiés peuvent être utilisés in vivo en tant qu'agonistes du récepteur VPAC2. Les peptides de l'invention offrent un nouveau traitement pour des patients souffrant d'une baisse de la sécrétion endogène d'insuline, par exemple, des diabétiques de type 2.

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