A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/365 (2006.01) A61K 31/00 (2006.01) A61K 31/395 (2006.01) A61K 31/7048 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2490494
The present invention relates to compositions and methods to modulate .alpha.- secretase and/or to improve cognitive ability. The invention further relates the improved/enhanced cognitive ability in diseased individuals, particularly Alzheimer~s Disease patients, and treatment thereof through increased sAPP production. Macrocyclic lactones (i.e. bryostatin class and neristatin class) are compounds preferred for use with the present composition. The present invention also provides methods for increasing the generation of non- amyloidogenic soluble APP comprising the activation of protein kinase C (PKC) by administering an effective amount of PKC activator(s).
La présente invention concerne des compositions et des procédés qui permettent de moduler l'A-secrétase et/ou d'améliorer la capacité cognitive. L'invention se rapporte en outre à une capacité cognitive améliorée/renforcée chez des personnes atteintes d'une maladie, en particulier chez des patients souffrant de la maladie d'Alzheimer, et à un traitement de ces dernières reposant sur une prodution augmentée de la sAAP. Les lactones macrocycliques (par ex. de la classe de la bryostatine et de la classe de la néristatine) sont les composés préférés utilisés selon la présente invention. L'invention concerne également des procédés qui permettent d'augmenter la production de l'APP soluble non amyloïdogénique en activant la protéine kinase C (PKC) par l'administration d'une quantité efficace d'au moins un activateur de PKC.
Alkon Daniel L.
Etcheberrigaray Rene
Blanchette Rockefeller Neurosciences Institute
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
LandOfFree
Pkc activation as a means for enhancing sapp.alpha.... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pkc activation as a means for enhancing sapp.alpha...., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pkc activation as a means for enhancing sapp.alpha.... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1451582