Pla2 inhibitors and their use for inhibition of intestinal...

Details Pla2 inhibitors and their use for inhibition of intestinal... Pla2 inhibitors and their use for inhibition of intestinal...

C - Chemistry, Metallurgy

07

C

C07C 229/44 (2006.01) A61K 31/05 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/196 (2006.01) A61K 31/215 (2006.01) A61K 31/275 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) C07C 255/58 (2006.01) C07C 323/36 (2006.01) C07C 323/63 (2006.01) C07D 207/04 (2006.01) C07D 207/08 (2006.01)

Patent

CA 2191775

Certain compounds have been synthesized and found to be effective inhibitors of phospholipase A2 (PLA2), and thereby useful in the treatment of intestinal cholesterol absorption and the disease states arising therefrom, such as hypercholesterolemia and coronary artery disease.

On a trouvé que certains composés synthétisés sont des inhibiteurs efficaces de la phospholipase A¿2? (PLA¿2?), et sont donc utiles dans le traitement de l'absorption intestinale de cholestérol et d'états pathologiques qui en découlent, tels que l'hypercholestérolémie et les coronaropathies.

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