Plant bioreactor for the production of interleukin-24 cytokine

Details Plant bioreactor for the production of interleukin-24 cytokine Plant bioreactor for the production of interleukin-24 cytokine

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) A01H 5/00 (2006.01) A61K 36/00 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07K 14/54 (2006.01) C07K 14/78 (2006.01) C12N 15/65 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2695809

The production of interleukin-24 (IL-24) cytokine in plants is described. A plant optimized nucleic acid molecule encoding a IL-24 polypeptide is disclosed. Also described are genetic constructs comprising a regulatory region operably linked to a plant optimized nucleic acid molecule encoding a IL-24 polypeptide. The regulatory region may be an inducible promoter. Also disclosed are methods of transforming a plant, portion thereof, or plant cell with the genetic construct and method of using a plant, a portion of a plant or a plant cell that expresses IL-24.

L'invention concerne la production de cytokine interleukine-24 (IL-24) dans des plantes. L'invention concerne également une molécule d'acide nucléique d'origine végétale optimisée codante pour un polypeptide IL-24. L'invention concerne aussi des constructions génétiques comprenant une région régulatrice fonctionnellement liée à une molécule d'acide nucléique d'origine végétale optimisée codant pour un polypeptide IL-24. La région régulatrice peut être un promoteur inductible. L'invention concerne en outre des procédés destinés à transformer une plante, une partie de plante ou une cellule végétale à l'aide de la construction génétique, et des procédés d'utilisation d'une plante, d'une partie de plante ou d'une cellule végétale qui exprime IL-24.

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