Plant defensin variants with modified systein residues

Details Plant defensin variants with modified systein residues Plant defensin variants with modified systein residues

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01) A01H 5/00 (2006.01) C07K 14/415 (2006.01) A01N 65/00 (2006.01)

Patent

CA 2378441

A modified cysteine-containing antimicrobial peptide derived from a plant defensin said modification comprising (a) introducing one or more cysteine residues and/or (b) replacing or altering one or more, cysteine residues to block their ability to form disulphide bridges. The modified peptides can have improved antimicrobial activity.

L'invention concerne un peptide antimicrobien modifié contenant une cystéine et dérivé d'une défensine végétale, la modification consistant : (a) à introduire un ou plusieurs résidus de cystéine et/ou (b) à remplacer ou à modifier un ou plusieurs résidus de cystéine afin de bloquer leur capacité de former des liaisons disulfure. Les peptides modifiés peuvent posséder une activité antimicrobienne améliorée.

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