Plant extracts for treatment of angiogenesis and metastasis

A - Human Necessities – 61 – K

Patent

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Details

A61K 36/00 (2006.01) A61K 38/56 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2536604

Extracts from plant material, or semi-purified/purified molecules or compounds prepared from the extracts that demonstrate the ability to modulate one or more cellular activities are provided. The extracts are capable of slowing down, inhibiting or preventing cell migration, for example, the migration of endothelial cells or neoplastic cells and thus, the use of the extracts to slow down, inhibit or prevent abnormal cell migration in an animal is also provided. Methods of selecting and preparing the plant extracts and methods of screening the extracts to determine their ability to modulate one or more cellular activity are described. The purification or semi-purification of one or more molecules from the described extracts is also contemplated as well as the use of these molecules, alone or in combination with an extract, to slow down, inhibit or prevent abnormal cell migration in an animal.

La présente invention a trait à des extraits dérivés de matière végétale, ou des molécules ou composés semi-purifiés/purifiés préparés à partir des extraits présentant la capacité de moduler une ou des activités cellulaires. Les extraits sont capables de ralentir, d'inhiber ou de prévenir la migration cellulaire, par exemple, la migration de cellules endothéliales ou de cellules néoplasiques et par conséquent, l'invention a également trait à l'utilisation des extraits pour le ralentissement, l'inhibition ou la prévention de migration cellulaire anormale chez un animal. L'invention a trait en outre à des procédés de sélection et de préparation d'extraits végétaux et des procédés de criblage des extraits en vue de déterminer leur capacité de moduler une ou des activités cellulaires. L'invention a trait enfin à la purification ou la semi-purification d'une ou de plusieurs molécules dérivées des extraits de l'invention ainsi que l'utilisation desdites molécules, seules ou en combinaison avec un extrait, pour le ralentissement, l'inhibition ou la prévention de migration cellulaire anormale chez un animal.

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