Plant production of immunoglobulins with reduced fucosylation

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) C07K 16/00 (2006.01) C07K 16/08 (2006.01) C07K 16/28 (2006.01) C12N 15/82 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2506744

This invention provides for the plant production of immunoglobulins, wherein at least a portion of the glycans attached to the immunoglobulins lack fucose. The invention also provides the constructs; plasmids; vectors; transformed plant cells, transformed plant calli, transformed plant tissues (e.g., leaves, seeds, tubers, etc.) and transformed whole plants used to produce such immunoglobulins; methods of producing the immunoglobulins; the immunoglobulins produced by the disclosed methods; and the use of such immunoglobulins.

L'invention concerne la production végétale d'immunoglobulines. Au moins une partie des glycanes fixés à ces immunoglobulines manque de fucose. L'invention concerne également des constructions ; des plasmides ; des vecteurs; des cellules végétales transformées, des cals végétaux transformés, des tissus végétaux transformés (par exemple, des feuilles, des graines, des tubercules, etc.) et des végétaux entiers transformés, utilisés pour produire de telles immunoglobulines. L'invention concerne également des méthodes de production de ces immunoglobulines, les immunoglobulines produites par ces méthodes; et l'utilisation de ces immunoglobulines.

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