C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) A61K 45/06 (2006.01) A61K 48/00 (2006.01) C12N 9/52 (2006.01) C12N 15/10 (2006.01) C12N 15/52 (2006.01)
Patent
CA 2485182
This invention relates to novel plant thymidine kinases and their use in gene therapy. More specifically the invention provides novel thymidine kinases derived from tomato, pine, rice or thale cress. In further aspects the invention provides novel polynucleotides encoding the plant thymidine kinases, vector constructs comprising the polynucleotide, host cells carrying the polynucleotide or vector, methods of sensitising cells to prodrugs, methods of inhibiting pathogenic agents in warm-blooded animals, methods for biocontrol of plants, methods of synthesizing monophosphates and pharmaceutical compositions comprising the plant thymidine kinases of the invention. In a preferred embodiment the invention provides a unique combination of a plant thymidine kinase and the nucleoside analog AZT to treat abnormal cell growth.
L'invention concerne de nouvelles thymidines kinases d'origine végétale et leurs applications en thérapie génique. L'invention concerne plus précisément de nouvelles thymidines kinases dérivées de la tomate, du pin, du riz ou de l'arabette des dames. D'autres aspects de l'invention concernent de nouveaux polynucléotides codant pour ces thymidines kinases d'origine végétale, des constructions de vecteurs comprenant ces polynucléotides, des cellules hôte transportant ce polynucléotide ou ce vecteur, des méthodes permettant de sensibiliser des cellules à des promédicaments, des méthodes permettant d'inhiber des agents pathogènes chez des animaux à sang chaud, des méthodes de lutte biologique, des méthodes permettant de synthétiser des monophosphates et des compositions pharmaceutiques contenant les thymidines kinases d'origine végétale de l'invention. Un mode de réalisation préféré de l'invention concerne une combinaison unique formée d'une thymidine kinase d'origine végétale et de l'analogue nucléosidique AZT, utilisée pour le traitement de la croissance cellulaire anormale.
Knecht Wolfgang
Munch-Petersen Birgitte
Piskur Jure
Knecht Wolfgang
Mccarthy Tetrault Llp
Munch-Petersen Birgitte
Piskur Jure
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