Plants which synthesize increased amounts of glucosaminoglycans

Details Plants which synthesize increased amounts of glucosaminoglycans Plants which synthesize increased amounts of glucosaminoglycans

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01)

Patent

CA 2698989

The present invention relates to plant cells and plants which synthesize an increased amount of glucosaminoglycans, and to methods for preparing such plants, and also to methods for preparing glucosaminoglycans with the aid of these plant cells or plants. Here, plant cells or genetically modified plants according to the invention have glucosaminoglycan synthase activity and additionally an increased glucosamine 6- phosphate acetyltransferase activity and an increased UDP-N-acetyl-glucosamine pyrophosphorylase activity compared to wild-type plant cells or wild-type plants. The present invention furthermore relates to compositions comprising plant cells having an increased glucosaminoglycan synthesis.

La présente invention concerne des cellules végétales et des plantes qui synthétisent une quantité accrue de glucosaminoglycannes, des procédés pour préparer de telles plantes, ainsi que des procédés pour préparer des glucosaminoglycannes à l'aide de ces cellules végétales ou de ces plantes. Selon l'invention, les cellules végétales ou plantes génétiquement modifiées ont une activité de glucosaminoglycanne synthase et, de plus, une activité glucosamine 6-phosphate acétyltransférase accrue et une activité UDP-N-acétyl-glucosamine-pyrophosphorylase accrue par comparaison avec les cellules végétales de type sauvage ou les plantes de type sauvage. La présente invention concerne en outre des compositions comportant des cellules végétales présentant une synthèse accrue de glucosaminoglycanne.

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