Plasma carboxypeptidase b inhibitors

C - Chemistry – Metallurgy – 07 – F

Patent

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Details

C07F 9/38 (2006.01) A61K 31/195 (2006.01) A61K 31/445 (2006.01) A61K 31/661 (2006.01) A61K 31/662 (2006.01) A61K 31/67 (2006.01) A61K 31/675 (2006.01) A61P 9/10 (2006.01) C07C 323/58 (2006.01) C07D 211/34 (2006.01) C07F 9/06 (2006.01) C07F 9/6524 (2006.01) C07F 9/6541 (2006.01) C07F 9/6553 (2006.01)

Patent

CA 2479892

Compounds of the following formula (I), for example: (1), wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions containing these compounds, methods of using these compounds as antithrombotic agents and processes for synthesizing these compounds are also described herein.

L'invention porte sur des composés représentés par la formule (I), dans laquelle, par exemple : (1) R?1¿, R?2¿, R?3¿, et R?4¿ tels que décrits ci-après sont utiles en tant qu'inhibiteurs de plasma carboxypeptidase B. L'invention concerne des compositions pharmaceutiques contenant ces composés, des procédés d'utilisation de ces composés en tant qu'agents antithrombotiques et des procédés de synthèse de ces composés.

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