Plasma concentrate and tissue sealant compositions

A - Human Necessities – 61 – L

Patent

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Details

A61L 24/00 (2006.01) A61K 35/14 (2006.01) A61L 24/10 (2006.01) A61M 1/34 (2006.01) A61M 1/36 (2006.01) B01D 15/00 (2006.01) B01D 17/038 (2006.01) B01D 61/18 (2006.01) B01D 63/16 (2006.01) B01D 67/00 (2006.01) B04B 5/04 (2006.01)

Patent

CA 2182862

An inexpensive device, shown in the figure, for preparing tissue sealant is disclosed. The device is particularly applicable to preparation of autologous tissue sealant. A method of sealing tissue in which the tissue sealant is applied immediately after mixing platelet-rich plasma concentrate with a solution of calcium and thrombin is also disclosed. Adhesive and tensile strengths are comparable or superior to pooled blood fibrin sealants made with precipitation methods. Antifibrinolytic agents are not necessary because the tissue sealant contains high concentrations of natural inhibitors of fibrinolysis from the patient's blood. The tissue sealant also contains patient platelets and additional factors not present in available fibn sealants that promote wound healing:

Dispositif peu coûteux de préparation d'un agent de scellement tissulaire. Le dispositif s'applique notamment à la préparation d'un agent de scellement tissulaire autologue. L'invention concerne également un procédé de scellement de tissu dans lequel l'agent de scellement tissulaire est appliqué immédiatement après mélange du concentré de plasma riche en plaquettes à une solution de calcium et de thrombine. La force d'adhérence et la résistance à la traction sont comparables ou supérieures à celles d'agents de scellement constitués de fibrine du sang regroupés, obtenus par des procédés de précipitation. Des agents antifibrinolytiques ne sont pas nécessaires du fait que l'agent de scellement tissulaire contient des concentrations élevées d'inhibiteurs naturels de la fibrinolyse provenant du sang du patient. L'agent de scellement tissulaire contient également des plaquettes du patient ainsi que des facteurs supplémentaires non présents dans des agents de scellement à base de fibrine disponible, lesquels stimulent la cicatrisation de lésions.

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