Plasma-depleted, non-red blood cell-depleted cord blood...

Details Plasma-depleted, non-red blood cell-depleted cord blood... Plasma-depleted, non-red blood cell-depleted cord blood...

A - Human Necessities

01

N

A01N 1/02 (2006.01)

Patent

CA 2609266

The umbilical cord blood (UCB) compositions of the present invention possess the unique features of having plasma that is substantially depleted from the UCB unit and red blood cells (RBC) that are not depleted from the UCB unit. Such UCB units can be prepared by a process that combines plasma depletion with cryopreservation, selection, thawing, and/or transplantation of hematopoietic stem cells to provide superior clinical outcome by maximizing post-processing cell recovery and post-thaw infusion cell dose. Methods for treating a wide variety of malignant diseases and benign diseases associated with the hematopoietic system by administering the UCB compositions of the present invention are also provided.

L'invention concerne des compositions de sang ombilical (UCB) présentant des caractéristiques uniques, à savoir un plasma sensiblement appauvri provenant de l'unité de sang ombilical, et des globules rouges (RBC) non appauvris provenant de l'unité (UCB). De telles unités (UCB) peuvent être préparées par un procédé qui combine un appauvrissement en plasma à une cryoconservation, à une sélection, à une décongélation ou à une transplantation de cellules souches hématopoïétiques pour obtenir des résultats cliniques supérieurs par la maximisation de la récupération cellulaire post-traitement et de la dose cellulaire de perfusion post-décongélation. L'invention concerne également des méthodes pour traiter une grande variété de maladies malignes et de maladies bénignes associées au système hématopoïétique, ces méthodes consistant à administrer les compositions UCB de l'invention.

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