Plasma-like solution

Details Plasma-like solution Plasma-like solution

A - Human Necessities

61

K

A61K 35/16 (2006.01) A01N 1/02 (2006.01) A61K 33/10 (2006.01) A61K 33/14 (2006.01) A61L 2/04 (2006.01)

Patent

CA 2164321

Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and maguesium, and a dissolved organic salt of sodium are disclosed. The solutions are effective substitutes for blood and may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution. The solutions may be used for maintaining a partially or substantially completely exsanguinated subject at normal temperatures and at temperatures substantially below those normally maintained by a mammal and may be used in conjunction with hypobaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject.

Solutions aqueuses comportant un agent oncotique aux polysaccharides, un tampon physiologiquement compatible, un sucre hexose simple, des sels de chlorure de calcium, sodium et magnésium dissous et un sel organique de sodium dissous. Ces solutions constituent des substituts sanguins efficaces et peuvent être utilisées pour préserver l'intégrité biologique des organes d'un mammifère donneur, comme l'indique l'excellente intégrité anatomique des organes et tissus, conservés par cryopréservation, de sujets qui ont été perfusés avec la solution. Ces solutions peuvent être utilisées pour maintenir un sujet partiellement ou totalement exsanguiné à des températures normales et à des températures sensiblement inférieures à celles normalement maintenues par un mammifère, et elles peuvent être associées à des conditions hypobares pour maintenir ces sujets partiellement ou totalement exsanguinés en vie sans leur transfuser de sang.

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