Plasma surface graft process for reducing thrombogenicity

Details Plasma surface graft process for reducing thrombogenicity Plasma surface graft process for reducing thrombogenicity

A - Human Necessities

61

L

A61L 33/00 (2006.01) A61F 2/06 (2006.01) B29C 59/14 (2006.01)

Patent

CA 2438624

In accordance with the present invention, there is provided a novel process for modifying the surface properties of a material that is suitable for contact with animal tissue so as to enhance its hemocompatibility and make it less thrombogenic when in use. This process comprises: Exposing the surface of the material to plasma treatment conditions in order to create reactive groups on said surface; activating a molecule with an activator to produce a reactive molecular species capable of forming convalent bonds with the reactive groups created on the surface of the material to form convalent bonds. The invention further encompasses the materials produced by this process as well as devices, such as vascular prosthesis, that are comprised of these process-modified materials.

La présente invention concerne un procédé pour modifier les propriétés de surface d'un matériau adapté au contact avec des tissus animaux, de façon à améliorer son hémocompatibilité et à le rendre moins thrombogène lors de son utilisation. Ce procédé consiste à mettre la surface dudit matériau dans des conditions de traitement au plasma, afin de créer des groupes réactifs à ladite surface, puis à activer une molécule à l'aide d'un activateur, afin de produire une espèce moléculaire réactive pouvant former des liaisons covalentes avec les groupes réactifs créés à la surface du matériau, afin de former des liaisons covalentes. La présente invention concerne également les matériaux produits selon ce procédé, ainsi que des dispositifs, tels que des prothèses vasculaires, qui sont constitués de ces matériaux modifiés à l'aide dudit procédé.

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