Plasmid encoding fibroblast growth factor for the treatment...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/727 (2006.01) A61K 38/18 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2526792

The present invention relates to the use of a plasmid encoding a fibroblast growth factor as therapeutic agent for the prevention and treatment of hypercholesterolemia or diabetes associated myocardial or skeletal angiogenic defects. The present invention also relates to a method for enhancing formation of both collateral blood vessels and arterioles in myocardial or skeletal ischemic tissues in a mammalian subject suffering from hypercholesterolemia or diabetes. The present invention further relates to a method of promoting collateral blood vessels in ischemic myocardial or skeletal tissues without inducing VEGF-A factor expression and causing edema in the treated muscles.

La présente invention concerne l'utilisation d'un plasmide codant un facteur de croissance des fibroblastes comme agent thérapeutique pour la prévention et le traitement de l'hypercholestérolémie ou du diabète associé à des anomalies angiogéniques du myocarde ou du squelette. Elle concerne également un méthode pouvant améliorer la formation tant des vaisseaux sanguins colatéraux que des artérioles dans des tissus ischémiques du myocarde ou du squelette d'un sujet mammalien souffrant d'hypercholestérolémie ou de diabète. L'invention concerne en outre une méthode pouvant activer les vaisseaux sanguins colatéraux dans des tissus ischémiques du myocarde ou du squelette, sans susciter l'expression du facteur VEGF-A ni provoquer un oedème dans les muscles traités.

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