Plasmid vector with pectate lyase signal sequence

Details Plasmid vector with pectate lyase signal sequence Plasmid vector with pectate lyase signal sequence

C - Chemistry, Metallurgy

12

N

195/1.2, 195/1.2

C12N 15/70 (2006.01) C07K 14/43 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 1/21 (2006.01) C12N 9/88 (2006.01) C12N 15/11 (2006.01) C12N 15/13 (2006.01) C12N 15/29 (2006.01) C12N 15/60 (2006.01) C12N 15/62 (2006.01) C12N 15/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1338807

The DNA coding for pectate lyase signal peptide has been cloned on a plasmid to create a secretion vector which is capable of producing a chosen protein that will be transported across the bacterial membrane. The secretion vector has been used to secrete extracellular thaumatin and extracellular chimeric antibodies. The proteins produced by this vector have biological activity. The thaumatin is properly folded and the antibodies are capable of binding antigens on target cancer cells.

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