Plasmids with immunological action

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/145 (2006.01) A61K 48/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C12N 15/79 (2006.01)

Patent

CA 2660324

Recombinant plasmids usable for the transfection of eukaryotic and prokaryotic cells are described; such plasmids have a length comprised between 7 and 12 kbases and comprise a sequence encoding the heavy chain of an immunoglobulin; in particular, they may be used: -in a process of transfection of prokaryotic or eukaryotic cells (ex vivo) which can be inoculated into higher organisms in order to induce a prophylactic or therapeutic immune response; -in a protocol of direct inoculation (in vivo) in higher organisms in genie immunization methodologies with the aim of evoking prophylactic or therapeutic immune responses.

L'invention concerne des plasmides recombinants utilisables pour transfecter des cellules eucaryotes et procaryotes. Ces plasmides ont une longueur comprise entre 7 et 12 kilobases et ils comprennent une séquence codant pour la chaîne lourde d'une immunoglobuline. Ils peuvent être utilisés notamment : - dans un procédé de transfection de cellules procaryotes ou eucaryotes (ex vivo) qui peuvent être inoculées à des organismes supérieurs afin d'induire une réponse immunitaire prophylactique ou thérapeutique; - dans un protocole d'inoculation directe (in vivo) d'organismes supérieurs dans des méthodologies d'immunisation génique visant à déclencher des réponses immunitaires prophylactiques ou thérapeutiques.

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