Plasminogen activator as an anti-inflammatory agent

Details Plasminogen activator as an anti-inflammatory agent Plasminogen activator as an anti-inflammatory agent

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61K 38/49 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2278823

Plasminogen activator acts as an anti-inflammatory agent by inhibiting generation of superoxide anion by a mechanism that is not related to L- arginine, is not dependent on thrombolytic activity, and is not a function of oxygen free radical scavenging. Moreover, in in vivo models of inflammation, treatment with plasminogen activator reduces edema without inhibiting neutrophil infiltration in in vivo models of inflammation.

L'activateur du plasminogène agit comme un agent anti-inflammatoire en inhibant la production d'anions superoxydes par un mécanisme qui n'est pas en rapport avec la L-arginine, qui n'est pas dépendant de l'activité thrombolytique et qui n'est pas fonction d'un piégeage des radicaux libres oxygène. En outre, dans les modèles in vivo de l'inflammation, le traitement avec l'activateur du plasminogène réduit les oedèmes sans inhiber l'infiltration neutrophile dans les modèles de l'inflammation in vivo.

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