C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 195/39.1
C12N 15/58 (2006.01) C12N 1/20 (2006.01) C12N 5/10 (2006.01) C12N 9/68 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2025743
ABSTRACT OF THE DISCLOSURE A TPA derivative with replacement of amino acids is provided. In a typical embodiment, the deriv- ative has an amino acid sequence with replacement of at least one amino acid selected from the group consisting of asparagine at the 37th position, serine at the 38th position, glycine at the 39th position, arginine at the 40th position, alanine at the 41st position, and gluta- mine at the 42nd position from the N-terminus of the amino acid sequence of natural tissue plasminogen activator.
Ikenaka Yasuhiro
Kakutani Tetsu
Matsumoto Keiji
Nagaoka Tetsuya
Yahara Hitoshi
Ikenaka Yasuhiro
Kakutani Tetsu
Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
Marks & Clerk
Matsumoto Keiji
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