Plasminogen activator derivatives

Details Plasminogen activator derivatives Plasminogen activator derivatives

A - Human Necessities

61

K

195/127, 195/35.

A61K 9/10 (2006.01) A61K 47/48 (2006.01) C12N 9/72 (2006.01) C12N 9/96 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1203764

ABSTRACT OF THE DISCLOSURE A derivative of a human-originated non-immunogenic plasminogen activator is disclosed which comprises at least one polyalkylene glycol attached with at least one coupling agent to amino acid side chains of said plasmino- gen activator, said polyalkylene glycol having a molecular weight of 200 - 20,000 and optionally containing one or more alkyl and/or alkanoyl groups as substituents. Also disclosed are a process for producing such derivative and a thrombolytic agent containing such derivative.

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