Plasminogen activator, its preparation process and...

Details Plasminogen activator, its preparation process and... Plasminogen activator, its preparation process and...

C - Chemistry, Metallurgy

12

N

167/103.33

C12N 9/64 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1221029

ABSTRACT Novel plasminogen activator having certain specific properties. The plasminogen activator can be prepared by subjecting a human kidney or human blood vessel to an extraction treatment with an ammonium thiocyanate solution and then causing the resultant extract to pass through a column loaded with an ion exchange material, a column loaded with a metal chelate, a column loaded with L-arginine or an arginine derivative bound on a carrier, a column loaded with a hemagglutinin bound to a carrier, or a column loaded with a carrier having molecular sieve effect to purify same. A thrombolytic agent containing the plasminogen activator as an active ingredient exhibits a strong thrombolytic activity but shows little side effects.

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