C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 38/48 (2006.01) C12N 9/68 (2006.01)
Patent
CA 2360690
Fragments of an endothelial cell proliferation inhibitor and method of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically is an angiostatin kringle 4 region fragment. The kringle 4 region fragments generally correspond to kringle 4 structures occurring within the endothelial cell proliferation inhibitor. The endothelial cell inhibiting activity of these fragments provides a means for inhibiting angiogenesis of tumors and for treating angiogenic-mediated disease.
L'invention concerne des fragments d'un inhibiteur de prolifération de cellules endothéliales et un procédé d'utilisation associé. L'inhibiteur de prolifération de cellules endothéliales est une protéine dérivée du plasminogène, ou plus spécifiquement un fragment de région kringle 4 d'angiostatine. Les fragments de région kringle 4 correspondent généralement à des structures de kringle 4 présentes dans l'inhibiteur de prolifération de cellules endothéliales. L'activité inhibitrice de cellules endothéliales de ces fragments constitue un moyen permettant d'inhiber l'angiogenèse de tumeurs et de traiter des affections induites par l'angiogenèse.
Folkman M. Judah
O'reilly Michael S.
Shing Yuen W.
Children's Medical Center Corporation
Finlayson & Singlehurst
Folkman M. Judah
O'reilly Michael S.
Shing Yuen W.
LandOfFree
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