Plasmodium falciparum ama-1 protein and uses thereof

Details Plasmodium falciparum ama-1 protein and uses thereof Plasmodium falciparum ama-1 protein and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/30 (2006.01) A61K 39/015 (2006.01) A61P 33/02 (2006.01) C07K 14/445 (2006.01) C07K 16/20 (2006.01) C12P 21/02 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2441952

In this application is described the expression and purification of a recombinant Plasmodium falciparum (3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

La présente invention concerne l'expression et la purification d'un ectodomaine de la protéine AMA-1 de Plasmodium falciparum (3D7). Le procédé de la présente invention permet de produire une protéine hautement purifiée retenant le repliement et la formation de liaisons disulfure de la molécule native. La protéine AMA-1 recombinée est utile comme réactif diagnostique et peut être utilisée pour la production d'anticorps et comme vaccin.

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