Plasmodium vaccines, antigens, compositions, and methods

Details Plasmodium vaccines, antigens, compositions, and methods Plasmodium vaccines, antigens, compositions, and methods

A - Human Necessities

61

K

A61K 39/00 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2738756

The present invention relates to the intersection of the fields of immunology and protein engineering, and particu-larly to antigens and vaccines useful in prevention of infection by Plasmodium parasites. Provided are recombinant protein anti-gens, compositions, and methods for the production of such antigens in plants. In some embodiments, Plasmodium antigens in-clude Pfs25 polypeptides, Pfs28 polypeptides, Pfs48/45 polypeptides, Pfs230 polypeptides, and/or combinations thereof.

La présente invention concerne l'intersection des domaines de l'immunologie et de l'ingéniérie des protéines et en particulier des antigènes et des vaccins qui peuvent être utilisés pour prévenir l'infection par le parasite plasmodium. L'invention propose des antigènes et des compositions de protéines recombinées ainsi que des procédés de production de ces antigènes chez les plantes. Dans certains modes de réalisation, les antigènes de plasmodium comprennent les polypeptides Pfs25, les polypeptides Pfs28, les polypeptides Pfs48/45, les polypeptides Pfs230 et/ou leurs combinaisons.

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