Plasmon resonant particles, methods and apparatus

G - Physics – 01 – N

Patent

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Details

G01N 21/63 (2006.01) C12Q 1/68 (2006.01) G01N 21/47 (2006.01) G01N 21/55 (2006.01) G01N 33/543 (2006.01) G01N 33/553 (2006.01)

Patent

CA 2280794

A method and apparatus for interrogating a target having a plurality of plasmon resonant particles (PREs) distributed in the target are disclosed. In the method, a field containing the target is illuminated, and one or more spectral emission characteristics of the light-scattering particles in the field are detected. From this data, an image of positions and spectral characteristic values in the field is constructed, allowing PREs with a selected spectral signature to be discriminated from other light-scattering entities, to provide information about the field. Also disclosed are a novel PRE composition for use in practicing the method, and a variety of diagnostic applications of the method.

Cette invention se rapporte à un procédé et à un dispositif permettant d'interroger une cible incorporant une pluralité de particules résonantes de type plasmon (PRE). Selon ce procédé, on éclaire un champ contenant la cible et l'on détecte au moins une caractéristique d'émission spectrale des particules de diffusion de la lumière se trouvant dans le champ. A partir de ces données, on élabore une image des positions et des valeurs de caractéristiques spectrales dans le champ, ce qui permet de distinguer les PRE associées à une signature spectrale sélectionnée d'autres entités de diffusion de la lumière, et d'obtenir ainsi des informations sur ledit champ. L'invention se rapporte également à une nouvelle composition contenant des PRE et utilisable pour la mise en oeuvre dudit procédé, ainsi qu'à une variété d'applications diagnostiques de ce procédé.

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