Plasters containing 4-biphenylacetic acid

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/192 (2006.01) A61K 9/70 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2380128

It is provided the plaster of anti-inflammatory and analgesic, improving the sustained releasing of 4-biphenylacetic acid from the base adhesive material and low skin irritation, by using more than two kinds of resolvent for 4-biphenylacetic acid having low solubility in solvents. More specifically, it is provided plasters essentially containing 5-50% by weight of styrene-isoprene-styrene block copolymer, 0.05-20% by weight of N-methyl-2-pyrrolidone, 0.1-20% by weight of polyethylene glycol and 0.1-20% by weight of 4-biphenylacetic acid.

L'invention porte sur un timbre analgésique, contenant de l'acide 4-biphénylacétique, un anti-inflammatoire peu soluble, et deux ou plus résorbeurs du médicaments, et assurant ainsi une meilleure libération de l'acide 4-biphénylacétique de la base tout en réduisant l'irritation de la peau. Ledit timbre comporte comme ingrédients essentiels: de 5 à 50 % en poids d'un copolymère bloc de styrène/isoprène/styrène, de 0,05 à 20 % en poids de N-méthyl-2-pyrrolidone, de 0,1 à 20 % en poids de polyéthylèneglycol, et de 0,1 à 20 % en poids d'acide 4-biphénylacétique.

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