C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/395 (2006.01) A61K 31/695 (2006.01) C07D 403/00 (2006.01) C07D 403/10 (2006.01) C07D 487/04 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2176247
The present invention relates to compounds of formula (I) and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
L'invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables de ces derniers constituant des antagonistes puissants du facteur d'activation plaquettaire et convenant au traitement de troubles relatifs audit facteur, dont l'asthme, l'état de choc, le syndrome de détresse respiratoire, l'inflammation aigüe, le rejet d'organe transplanté, l'ulcération gastro-intestinale, les affections allergiques cutanées, l'immunité cellulaire retardée, la parturition, la maturation pulmonaire foetale, et la différentiation cellulaire.
Carrera George M. Jr.
Curtin Michael L.
Davidsen Steven K.
Garland Robert B.
Heyman H. Robin
Abbott Laboratories
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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