Platelet adhesion inhibitor

Details Platelet adhesion inhibitor Platelet adhesion inhibitor

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/17 (2006.01) A61K 38/49 (2006.01) A61L 33/00 (2006.01) C07K 1/18 (2006.01)

Patent

CA 2093819

The inhibitor is protein derived leech tissue or leech secretions (for example, from Hirudo medicinalis), which is capable of binding to native collagen, in such a way that substantially no cleavage breakdown products of collagen molecules occur on SDS- PAGE. The protein substantially inhibits collagen-induced platelet aggregation or adhesion, has a molecular weight of 60-70 kilo- daltons in reduced form and has optimum activity at pH 8Ø

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