Platelet adp receptor inhibitors

Details Platelet adp receptor inhibitors Platelet adp receptor inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) A61P 9/00 (2006.01) C07D 239/22 (2006.01) C07D 239/50 (2006.01) C07D 333/34 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 411/12 (2006.01) C07D 417/14 (2006.01) C07D 495/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2400479

Novel compounds of formula (I) to (VI), which more particularly include sulfonylura derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfon-amide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I)-(VI), or a pharmaceutically acceptable salt thereof.

L'invention concerne des nouveaux composés de formule (I) à (IV). Plus particulièrement, ces composés comprennent des dérivés de sulfonylurée, des dérivés de sulfonylthiourée, des dérivés de sulfonylguanidine, des dérivés de sulfonylcyanoguanidine, des dérivés de thioacylsulfonamide et des dérivés d'acylsulfonamide constituant des inhibiteurs efficaces des récepteurs d'ADP des plaquettes. Ces dérivés peuvent être utilisés dans différentes compositions pharmaceutiques, et sont particulièrement efficaces dans la prévention et/ou le traitement de maladies cardiovasculaires, notamment des maladies liées à la thrombose. L'invention concerne également une méthode permettant de prévenir ou de traiter une thrombose chez un mammifère et consistant à administrer une dose thérapeutiquement efficace d'un composé de formule (I) à (IV) ou d'un sel pharmaceutiquement acceptable dudit composé.

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