Platelet aggregation inhibitor composition

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/00 (2006.01) A61K 38/00 (2006.01) A61P 7/02 (2006.01) C07K 14/435 (2006.01) C12N 15/09 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2625106

The invention provides a pharmaceutical composition comprising at least one polypeptide of the following (a) to (d): (a) a polypeptide comprising the amino acid sequence of SEQ ID NO:1; (b) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (a) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity; (c) a polypeptide comprising the amino acid sequence of SEQ ID NO:3; and (d) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (c) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity, as an active component.

La présente invention concerne une composition pharmaceutique comprenant en tant que matière active au moins un des polypeptides (a) à (d) suivants : (a) polypeptide comprenant la séquence d'acides aminés de SEQ ID NO : 1 ; (b) polypeptide comprenant une séquence d'acides aminés comprenant une ou plusieurs délétions, insertions, substitutions ou additions d'acides aminés dans la séquence d'acides aminés (a) ci-dessus et ayant une activité inhibitrice de l'agrégation plaquettaire et/ou une activité inhibitrice de l'adhésion plaquettaire ; (c) polypeptide comprenant la séquence d'acides aminés de SEQ ID NO : 3 ; et (d) polypeptide comprenant une séquence d'acides aminés comprenant une ou plusieurs délétions, insertions, substitutions ou additions d'acides aminés dans la séquence d'acides aminés (c) ci-dessus et ayant une activité inhibitrice de l'agrégation plaquettaire et/ou une activité inhibitrice de l'adhésion plaquettaire.

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