Platelet-aggregation inhibitors

Details Platelet-aggregation inhibitors Platelet-aggregation inhibitors

C - Chemistry, Metallurgy

07

K

530/5.04, 167/10

C07K 5/04 (2006.01) A61K 38/04 (2006.01) C07K 5/02 (2006.01) C07K 5/072 (2006.01) C07K 5/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2039628

4-18024/A/MA 1995 Novel Platelet-Aggregation Inhibitors Abstract of the Disclosure A compound having the formula I: Image (I) in which X is a group of formula: Image in which R1 is NHR4 in which R4 is H, acyl, alkoxycarbonyl or acyl, R2 is arylene, heteroarylene, alkenylene, CH2, O or NH, or any combination of these, R3 is H, NH2 or NH-acyl, in the R- or S- configuration, and m and n are each O or an integer from 1 to 5; Y is a group of formula: Image in which y is an integer ranging from 1 to 12; Z is NH2 or the radical of any of the common alpha-amino acids, or of the amides of such amino acids; and pharmacologically -compatible salts of the compound of formula I; provided that, when Y is Gly, X is other than Lys. The compounds of formu1a I are useful as platelet aggregation inhibitor.

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