Platelet aggregation inhibitors

Details Platelet aggregation inhibitors Platelet aggregation inhibitors

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 38/12 (2006.01) C07K 7/02 (2006.01) C07K 7/56 (2006.01) C07K 14/75 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2092315

2092315 9207870 PCTABS00013 A platelet aggregation inhibitor useful as an antithrombotic is provided which consists of a synthetic cyclic pentapeptide containing the tripeptide sequence Lys-Gly-Asp and a thioether linkage in the cycle. A prefered platelet aggregation inhibitor is represented by formula (I), where: R1 and R9 are OH; R2, R4, R5, R6, R7, R8 and R14 are hydrogen; R3 and R4 are joined to form a pyrrolidine ring; X is sulfur; m is 1 and n is 3.

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