Platelet derived growth factor antagonists

Details Platelet derived growth factor antagonists Platelet derived growth factor antagonists

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/10 (2006.01) A61K 38/18 (2006.01) C07K 7/08 (2006.01) C07K 14/49 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2135749

2135749 9323068 PCTABS00028 The invention describes antagonists for PDGF. The antagonists contain amino acids, and may be monomers or dimers. Especially preferred are dimers which bind the PDGF receptors, but prevent dimerization of the bound receptors. Dimerization is necessary for PDGF effect, hence the antagonistic effect. Also described are nucleic acid sequences for making the antagonists, as well as cell lines transfected with the material. The figure sets forth amino acid sequences for peptides eluted from PDGF-A HPLC experiments.

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