Platelet gpiiia p1 a1 and p1 a2 epitopes, their preparation...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2125486

Polypeptides and fusion polypeptides that immunologically mimic the native P1A1 and P1A2 determinants of platelet protein GPIIIa are disclosed. Also disclosed are DNA segments and recombinant DNA molecules that encode those polypeptides and fusion polypeptides and methods for expressing and using those determinants. Antibodies that immunoreact with one determinant or the other, but not both are also disclosed, as are methods of preparing and using those antibodies.

Polypeptides et polypeptides de fusion imitant de façon immunologique les déterminants natifs P1A1 et P1A2 de la GPIIIa plaquettaire. L'invention concerne également des segments d'ADN et des molécules d'ADN recombiné encodant ces polypeptides et polypetides de fusion et des méthodes d'expression et d'utilisation de ces déterminants. Sont également décrits des anticorps qui ont une réaction immunologique avec un déterminant ou l'autre, mais pas les deux, ainsi que des méthodes de préparation et d'utilisation de ces anticorps.

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