C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/535 (2006.01) A61K 38/19 (2006.01) A61P 7/00 (2006.01) A61P 7/04 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2183871
The invention relates to a polypeptide wherein at least one of the amino, carboxyl, mercapto or guanidino group in a polypeptide molecule having human granulocyte colony stimulating factor activity is chemically modified by a chemical modifying agent, and a platelet production promoter comprising said polypeptide, a method for treating a patient with decreased platelet counts comprising administering an effective amount of said polypeptide to the patient, the use of said polypeptide for the production of pharmaceutical compositions which are useful for the treatment of the patient with decreased platelet counts, and the compositions for treating the patient with decreased platelet counts, which comprises an effective dose of said polypeptide in a pharmaceutically acceptable dosage form with a pharmaceutical acceptable carrier.
La présente invention concerne un polypeptide stimulant les colonies de granulocytes humains, polypeptide dans lequel au moins un groupe amino, carboxy, mercapto ou guanidino a été chimiquement modifié par un modificateur chimique. L'invention concerne aussi un accélérateur de croissance des thrombocytes, accélérateur contenant ledit polypeptide. L'invention concerne également un procédé de traitement des patients thrombocytopéniques par administration dudit polypeptide à dose suffisante. L'invention concerne en outre l'utilisation dudit polypeptide pour la production d'une composition pharmacologique faisant preuve d'efficacité dans le traitement de patients thrombocytopéniques. L'invention concerne enfin une composition permettant le traitement de patients thrombocytopéniques grâce à une dose efficace dudit polypeptide formulé de façon pharmacologiquement acceptable en association avec un excipient pharmacologiquement acceptable.
Kobayashi Ken
Maruyama Kumiko
Okabe Masami
Suzawa Toshiyuki
Yamasaki Motoo
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Kyowa Hakko Kirin Co. Ltd.
Kyowa Hakko Kogyo Co. Ltd.
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