Platinum complex and medical compound containing same

C - Chemistry – Metallurgy – 07 – C

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C07C 211/38 (2006.01) A61K 31/555 (2006.01) A61P 35/00 (2006.01) C07C 55/06 (2006.01) C07C 61/04 (2006.01) C07F 15/00 (2006.01)

Patent

CA 2734125

A new platinum complex which has strong antitumor activity and has effect with smaller doses and a pharmaceutical composition containing the same are provided. A spiro[4,4]nonane-1,6-diamineplatinum(II) complex which is represented by a following general formula (A) .(In the formula, X and Y are same or different, and X and Y represent halogen atoms respectively, or X and Y cooperatively represent a divalent residue which is described by a formula (Z).) The platinum complex has a strong antitumor activity and is efficacious as a therapeutic agent for malignant tumors.

La présente invention concerne un nouveau complexe de platine, et un composé médical contenant celui-ci, qui a une activité antinéoplasique élevée et est efficace à des doses plus faibles. Le complexe de platine a une spiro[4,4]nonane-1,6-diamine représentée par la formule générale (A) en tant que ligand du complexe de platine. (Dans la formule, X et Y sont identiques ou différents, et chacun représente un atome dhalogène, ou X et Y représentent conjointement un résidu bivalent représenté par la formule (Z).) Ledit complexe de platine a une activité antinéoplasique élevée et est efficace en tant quagent thérapeutique pour des tumeurs malignes.

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