Platinum complex, its preparation and therapeutic application

Details Platinum complex, its preparation and therapeutic application Platinum complex, its preparation and therapeutic application

C - Chemistry, Metallurgy

07

F

C07F 15/00 (2006.01) A61K 31/282 (2006.01)

Patent

CA 2331464

Disclosed is a platinum complex of the general formula (I) wherein X represents a halogen atom and A represents a group -NH2-R wherein R is a tricyclic hydrocarbon moiety containing 10 to 14 carbon atoms which may be optionally substituted on the tricyclic ring by one or two alkyl group(s) containing 1 to 4 carbon atoms, and, furthermore, an inclusion complex of the above platinum complex with beta- or gamma cyclodextrin which may be optionally substituted by a hydroxyalkyl group of 1 to 6 carbon atoms. There are also disclosed a method for the preparation of the complex of the fomula (I) based on bringing into reaction a solution of an alkaline metal salt of ammin-trihalogenplatinate(II) in a polar organic solvent or in water with a primary amine of formula R-NH2, wherein R is a tricyclic hydrogen moiety containing to 14 carbon atoms, which may be optionally substituted on the tricyclic ring by one or two alkyl group(s) each containing 1 to 4 carbon atoms, at the temperature in the range of 0 to 100°C, as well as a method for manufacture of the above inclusion complex. The both disclosed complexes may be used as such or as a part of a pharmaceutical composition in a therapy of oncologic diseases.

L'invention concerne un complexe de platine représenté par la formule (I) dans laquelle X représente un atome d'halogène et A représente une amine primaire tricyclique contenant 10 à 14 atomes de carbone et pouvant être éventuellement substituée sur le noyau tricylique par un ou deux groupes alkyle contenant 1 à 4 atomes de carbone et, de plus, complexe d'inclusion dudit complexe de platine avec bêta- ou gamma-cyclodextrine pouvant être éventuellement substituée par un groupe hydroxyalkyle de 1 à 6 atomes de carbone. Elle concerne également un procédé servant à préparer ce complexe représenté par la formule (I) et consistant à provoquer la réaction d'une solution d'un sel de métal alcalin d'ammine-trihalogénoplatinate (II) dans un solvant organique polaire ou dans de l'eau avec l'amine tricyclique correspondante à une température située entre 0 et 100 DEG C, ainsi qu'un procédé servant à préparer ledit complexe d'inclusion. On peut mettre en application ces deux complexes seuls ou en tant que partie d'une composition pharmaceutique dans une thérapie de maladies cancéreuses.

Affiliated with

Also associated with

Rating

Platinum complex, its preparation and therapeutic application does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Platinum complex, its preparation and therapeutic application, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Platinum complex, its preparation and therapeutic application will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1789163