Platinum complexes for targeted drug delivery

G - Physics – 07 – F

Patent

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G07F 15/00 (2006.01)

Patent

CA 2587779

The subject invention concerns biotin-conjugated platinum complexes that exhibit direct and indirect (immunological) antitumor cell activity. The subject invention also concerns the biotin-platinum complexes of the invention that have another molecule, such as an antibody, a ligand, a receptor, etc., bound to the biotin moiety. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro

L'invention porte sur des complexes conjugués de biotine/platine présentant une activité antitumorale directe et indirecte (immunologique) sur des cellules. L'invention porte également sur des complexes de biotine/platine comportant une autre molécule telle qu'un anticorps, un ligand, ou un récepteur, liée au fragment de biotine. L'invention porte en outre sur l'utilisation desdits complexes de biotine/platine pour traiter les troubles oncologiques et inflammatoires. Lesdits complexes peuvent également servir à traiter ou prévenir in vivo ou in vitro des infections dues à un virus, une bactérie ou un organisme parasite.

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