Platinum(ii) complexes, preparation and use

Details Platinum(ii) complexes, preparation and use Platinum(ii) complexes, preparation and use

C - Chemistry, Metallurgy

07

F

C07F 15/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2547275

This invention relates to a method for the preparation of platinum(II) complexes, in particular dicarboxylatoplatinum(II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a bis-dicarboxylatoplatinate(II) species with a suitable neutral bidentate ligand to form a neutral dicarboxylatoplatinum(II) complex and, if necessary, recrystallising the product to form a pure dicarboxylatoplatinum(II) complex containing a neutral bidentate ligand. The invention also relates to a method for producing a bis- dicarboxylatoplatinate(II) species, and to new platinum(II) complexes that can be made by the method of the invention.

L'invention concerne un procédé pour la préparation de complexes de platine-II, notamment des complexes de dicarboxylatoplatine-II contenant un ligand bidenté neutre, tel que l'oxaliplatine. Ce procédé comporte l'étape consistant à faire réagir une espèce bis-dicarboxylatoplatinate-II avec un ligand bidenté neutre approprié pour former un complexe neutre de dicarboxylatoplatine-II et, si nécessaire, à faire recristalliser le produit pour former un complexe pur de dicarboxylatoplatine-II contenant un ligand bidenté neutre. L'invention concerne également un procédé pour produire une espèce bis-dicarboxylatoplatinate-II, et de nouveaux complexes de platine-II pouvant être fabriqués grâce au procédé ci-décrit.

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