C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 15/00 (2006.01) A61K 31/28 (2006.01) A61K 31/7135 (2006.01) A61P 29/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) C07C 323/12 (2006.01) C07D 213/22 (2006.01) C07D 233/84 (2006.01) C07D 235/28 (2006.01) C07D 239/38 (2006.01) C07D 473/38 (2006.01) C07H 23/00 (2006.01)
Patent
CA 2364712
A compound which is a complex of formula (I) wherein each X, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, aralkyl, alkaryl, acyl, halogen, haloalkyl, haloaryl, hydroxyalkyl, hydroxyaryl, aminoalkyl, aminoaryl, primary, secondary or tertiary amine, hydrazine, alkylhydrazine, alkoxyl, alkylthio, aralkoxyl, nitrile, ester, amide, nitro, azide or aziridino, or is a covalently linked chain which is joined to at least one other complex of formula (I) so as to form a dimeric or oligomeric species, or a covalently linked moiety which provides recognition for a target receptor; and Y is alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aralkyl, heterocyclyl, an inorganic oxyacid or inorganic oxyacid derivative, or a covalently linked chain which is joined to at least one other complex of formula (I) so as to form a dimeric or oligomeric species; or a pharmaceutically acceptable salt thereof, for use in a method of treatment of the human or animal body by therapy.
L'invention porte sur un composé consistant en un complexe de formule (I) dans laquelle chaque X, qui peut être identique ou différent, est hydrogène, alkyle, cycloalkyle, alcényle, cycloalcényle, alkynyle, aryle, hétérocyclyle, aralkyle, alkaryle, acyle, halogène, haloalkyle, haloaryle, hydroxyalkyle, hydroxyaryle, aminoalkyle, aminoaryle, amine primaire, secondaire ou tertiaire, hydrazine, alkylhydrazine, alkoxyle, alkylthio, aralkoxyle, nitrile, ester, amide, nitro, azide ou aziridino, ou est une chaîne liée par covalence et relié à au moins d'autres complexes de formule (I) de manière à former un fragment lié par covalence pouvant reconnaître un récepteur cible; et Y est alkyle, cycloalkyle, alcényle, cycloalcényle, alkynyle, aralkyle, hétérocyclyle, un oxacide minéral ou l'un de ses dérivés, ou une chaîne liée par covalence et relié à au moins d'autres complexes de formule (I) de manière à former un dimère ou un oligomére. L'invention porte également sur un de ses sels pharmacocompatible utilisable dans un procédé de traitement thérapeutique du corps de l'homme ou de l'animal.
Isis Innovation Ltd.
Kirby Eades Gale Baker
LandOfFree
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