Platinum (iv) complexes

Details Platinum (iv) complexes Platinum (iv) complexes

C - Chemistry, Metallurgy

07

F

C07F 15/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2691047

Provided are nitroplatinum(IV) complexes containing a bidentate dicarboxylate ligand (e.g., oxalate) which maybe useful treating various forms of proliferative diseases, such as cancer. In some instances the platinum(IV) complexes are relatively stable and may be suitable for oral administration. Also provided are methods of treatment, as well as kits and unit dosages.

L'invention porte sur des complexes de nitro-platine (IV) contenant un ligand de dicarboxylate bidentate (par exemple un oxalate) qui peut être utile pour traiter diverses formes de maladies prolifératives, telles que le cancer. Dans certains cas, les complexes de platine (IV) sont relativement stables et peuvent être appropriés pour une administration orale. L'invention concerne également des procédés de traitement, ainsi que des coffrets et des unités de dosage.

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