Platinum or palladium complexes

Details Platinum or palladium complexes Platinum or palladium complexes

A - Human Necessities

61

K

167/119, 403/2,

A61K 31/80 (2006.01) A61K 31/295 (2006.01) A61K 47/48 (2006.01) C07F 15/00 (2006.01) C07F 17/02 (2006.01)

Patent

CA 1227133

ABSTRACT OF THE INVENTION Compositions of matter are provided wherein cis-platinum (II) and cis- palladium (II) moieties having amine substituents are bonded to anionic macro- molecular entities. These compositions of matter may have improved solubility inthe plasma and are effective antitrypanosomal and antitumor agents in mammals. Alternatively, the compositions of matter may be insoluble in water and particu-larly adapted for in situ implantation into tumerous masses.

440644

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