C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 23/00 (2006.01) C07F 15/00 (2006.01)
Patent
CA 2045120
2045120 9008157 PCTABS00001 Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. Compounds having formula (I) wherein n is 0 or 1 and when n is 1, R1 is H or C1-C4 alkyl, R is non-substituted higher alkyl or mono or disaccharide or a derivative of a mono or disaccharide, when n is 0, R1 is H or C1-C4 alkyl, R is H, halogen, non-substituted C1-20 alkyl, aryl, aralkyloxy, mono or disaccharide, or a derivative of a mono or disaccharide, and R2 and R3 are selected from the group consisting of hydrogen, C1-4 alkyl or R2 and R3 or R2 and R3 together are linked to adjacent carbon atoms on a four, five or six membered ring structure, or R2 and R3 together form a fused or bicyclic ring with adjacent carbon atoms, or R2 and R3 together are a substituted or unsubstituted C1-5 alkylene group; with the proviso that R and R1 cannot both be hydrogen when n = 0, or a pharmaceutically acceptable salt thereof, are particularly useful.
Green Dianna C.
Schein Philip S.
Talebian Abdolhossen
Georgetown University
Kirby Eades Gale Baker
LandOfFree
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