Platinum-polymer complexes and their use as antitumor agents

Details Platinum-polymer complexes and their use as antitumor agents Platinum-polymer complexes and their use as antitumor agents

C - Chemistry, Metallurgy

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167/119, 402/7.3

C07F 15/00 (2006.01) A61K 31/28 (2006.01) A61K 33/24 (2006.01) C08F 8/44 (2006.01) C08G 79/00 (2006.01)

Patent

CA 1338823

Platinum(amine) complexes, when covalently linked to a water-soluble, biodegradable or biostable polymer, exhibit high antitumor activity at low dosages of plati- num against Ll2l0 and solid tumors. The complexes are platinum sguare planar complexes and octahedral struc- tures of the formulae Image Image and (I) (II) wherein A2 represents either 2 ammonia ligands, 2 mono- dentate amine ligands or a single bidentate amine ligand; P is either a biodegradable or a biostable but biocompatible polymer having pendent anionic groups which form covalent linkages with Pt; o is a positive integer and X is an anionic ligand.

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