C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61K 49/14 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2758415
Described herein are compositions and methods for cancer cell biomarkers, such as pancreatic ductal adenocarci-noma (PDAC) cell biomarkers, and binding molecules for diagnosis and treatment of cancer, e.g., PDAC. Methods of identifying "accessible" proteomes are disclosed for identifying cancer biomarkers, such as plectin-1, a PDAC biomarker. Additionally, imag-ing compositions are provided comprising magnetofluorescent nanoparticles conjugated to peptide ligands for identifying PDACs.
La présente invention concerne des compositions et procédés concernant des biomarqueurs de cellules cancéreuses, tels que les biomarqueurs de cellules de l'adénocarcinome du conduit pancréatique ou "PDAC" ( pancreatic ductal adenocarcinoma), et des molécules de liaison destinées au diagnostic et au traitement du cancer, tel que l'adénocarcinome du conduit pancréatique. L'invention concerne également des procédés permettant d'identifier des protéomes "accessibles" permettant d'identifier des biomarqueurs du cancer tels que la plectine-1 qui est un biomarqueur de l'adénocarcinome du conduit pancréatique. L'invention concerne en outre des compositions pour imagerie comprenant des nanoparticules magnéto-fluorescentes conjuguées à des ligands de peptides et permettant d'identifier l'adénocarcinome du conduit pancréatique.
Bardeesy Nabeel
Kelly Kimberly
Weissleder Ralph
Smart & Biggar
The General Hospital Corporation
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