C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/475 (2006.01) A61K 38/18 (2006.01) A61P 35/00 (2006.01) C07K 14/71 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) C12N 5/12 (2006.01) C12N 15/18 (2006.01) C12N 15/63 (2006.01) G01N 33/566 (2006.01) A61K 39/00 (2006.01) C12N 9/12 (2006.01)
Patent
CA 2412650
This invention relates to the discovery that pleiotrophin binds to and activates a pleiotrophin-receptor which is responsible for the events associated with pleiotrophin activity including tumorigenesis, cell proliferation, and cell invasion. By interfering with that association, the cascade of events associated with pleiotrophin activity can be prevented or reversed. Further, by evaluating the effect of different compounds and conditions on the interction, new drugs and treatments can be identified for use in preventing certains cancers and growth and developmental disorders.
L'invention porte sur une découverte selon laquelle la pléiotrophine se fixe à et active un récepteur de la pléiotrophine responsable d'événements associés à l'activité de la pléiotrophine dont la tumorogenèse, la prolifération cellulaire et l'invasion cellulaire. En jouant avec cette association, on peut prévenir ou inverser la cascade d'événements associés à l'activité de la pléiotrophine; en outre, en évaluant les effets de différents composés et états liés à ces interactions, on peut identifier de nouveaux médicaments et traitements de prévention de certains cancers, et de troubles de la croissance et du développement.
Georgetown University
Mbm Intellectual Property Law Llp
LandOfFree
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